스코폴라민 유도 기억력 손상 모델에서 새싹산양삼과 이를 포함한 경옥고 가미방의 기억력 개선 효과

초록

As the world population ages, the number of patients with dementia is expected to increase dramatically in the future. Ginseng (Panax ginseng C.A. Meyer) has many effects such as control of nerve function, control of body fluids and metabolic function, anti-diuretic, sexual enhancement, resistance to stress, improvement of digestion and absorption, and immune boosting effects. Kyung-Ok-Ko is widely used in traditional Korean medicine. The aim of this study is to investigate memory-enhancing properties of 70% ethanolic extracts of ginseng sprouts and modified Kyung-Ok-Ko. Alzheimer’s disease was induced by scopolamine treatment (1 mg/kg, i.p.) in mice. Passive avoidance and Y-maze tasks were performed by the mice to determine the effects of ginseng sprout extract and modified Kyung-Ok-Ko on memory. Ginseng sprout extract and modified Kyung-Ok-Ko significantly enhanced cognitive function and reduced scopolamineinduced cognitive impairment in mice. Compared to Kyung-Ok-Ko, modified Kyung-Ok-Ko had a significant memory-enhancing effect at a lower dose. Our findings suggest that ginseng sprout extract and modified Kyung-Ok-Ko attenuate cognitive impairment in mice.

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