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초록
Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds,cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.
키워드
Cordyceps militaris; militarin; anticancer activity; multi-gram scale
- 제목
- 동충하초에서 분리된 신규 항암물질의 효율적 합성법 개발
- 제목 (타언어)
- Development of an Efficient Synthetic Method for a Novel Anticancer Substance Isolated from Insect-flower
- 저자
- 차해연; 박해일; 트루옹넉투엔; 윤덕효; 김태웅; 성기호
- 발행일
- 2012-04
- 유형
- Y
- 저널명
- 약 학 회 지
- 권
- 56
- 호
- 2
- 페이지
- 71 ~ 73