Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

Pham, Tuan-Ahn. N.; Che, Haiyan; Phan, Phuong-Thuy T.; Lee, Jae-Won; Kim, Sung-Soo; Park, Haeil

doi:10.1016/j.bmcl.2012.01.135

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Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

Pham, Tuan-Ahn. N.;
Che, Haiyan;
Phan, Phuong-Thuy T.;
Lee, Jae-Won;
Kim, Sung-Soo;
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초록

A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2'-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC50 = 4.73 mu M) than that of wogonin (IC50 = 7.80 mu M). (C) 2012 Published by Elsevier Ltd.

키워드

Oroxylin A and its analogs; Wogonin; Inhibition of NO production; Anti-inflammatory activity; SCUTELLARIA-BAICALENSIS GEORGI; WOGONIN; FLAVONE; PGE(2)

제목: Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

저자: Pham, Tuan-Ahn. N.; Che, Haiyan; Phan, Phuong-Thuy T.; Lee, Jae-Won; Kim, Sung-Soo; Park, Haeil

DOI: 10.1016/j.bmcl.2012.01.135

발행일: 2012-04-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 22

호: 7

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