상세 보기
Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil
- Park, Han Na;
- Lee, Ji Hyun;
- Park, Sung-Kwan;
- Lee, Jongkook;
- Baek, Sun Young
WEB OF SCIENCE
8SCOPUS
9초록
A new tadalafil analogue was found in a commercial dietary supplement for enhancing sexual performance. The compound was detected by a high-performance liquid chromatography-diode array detector (HPLC-DAD). The analogue was isolated using semi-preparative HPLC, and its accurate mass was established by two LC-high-resolution-mass spectrometers (LC-HRMS). The structure was determined by nuclear magnetic resonance (NMR) spectroscopy. The accurate mass of the compound corresponded to a molecular formula of C24H23N3O4. The compound was identified as a structural analogue of tadalafil in which the N-methyl group of tadalafil was replaced with an N-isopropyl group. We have named the new analogue isopropylnortadalafil and it is first reported herein.
키워드
- 제목
- Identification of a new tadalafil analogue in commercial dietary supplements: isopropylnortadalafil
- 저자
- Park, Han Na; Lee, Ji Hyun; Park, Sung-Kwan; Lee, Jongkook; Baek, Sun Young
- 발행일
- 2017
- 유형
- Article
- 저널명
- Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
- 권
- 34
- 호
- 2
- 페이지
- 162 ~ 169
- 언어
- ENG
- 출판사
- TAYLOR & FRANCIS LTD
- 발행국가
- 영국
- 분량
- 8 페이지
- ISSN
- E 1944-0057
P 1944-0049