Two New Dihydrofuranoisoflavanones from the Leaves of Lespedeza maximowiczi and Their Inhibitory Effect on the Formation of Advanced Glycation End Products

초록

Two new dihydrofuranoisoflavanones, 2',4',5-trihydroxy-[5"-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2",3":7,8)]-(3S)-isoflavanone (1) and 2', 4', 5-trihydroxy-[5"-(1,2-dihydroxy-1-methylethyl)-dihydrofurano(2",3":7,8)]-(3R)-isoflavanone (2) as well as one already-known compound, (+)-catechin (3), were isolated from an n-BuOH soluble fraction from the leaves of Lespedeza maximowiczi. Spectroscopic data was used to elucidate the structures of compounds 1 and 2. All of the isolates were evaluated in vitro for their inhibitory activity on the formation of advanced glycation end products (AGEs). Among these, compounds 1, 2, and 3 exhibited inhibitory activity against AGEs formation with IC50 values of 20.6, 18.4, and 5.6 mu M, respectively.

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