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The native form of follicle-stimulating hormone is essential for the growth of mouse preantral follicles in vitro
- Kim, Keun Cheon;
- Park, Min Hee;
- Yun, Jung Im;
- Lim, Jeong Mook;
- Lee, Seung Tae
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2초록
To assess whether the follicle-stimulating hormone (FSH) subunits observed in patients with gonadotroph adenomas (GA) can cause infertility, the effects of subunits and heterodimeric FSH on the in vitro follicle development were evaluated in mice. The partial forms of FSH in follicle culture did not induce development into pseudoantral follicles, whereas follicles cultured with native FSH developed into pseudoantral follicles and produced mature metaphase II oocyte. Therefore, intact FSH is needed for folliculogenesis, implying that production of FSH with a partial structure in GA may result in infertility. (c) 2020 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.
키워드
- 제목
- The native form of follicle-stimulating hormone is essential for the growth of mouse preantral follicles in vitro
- 저자
- Kim, Keun Cheon; Park, Min Hee; Yun, Jung Im; Lim, Jeong Mook; Lee, Seung Tae
- 발행일
- 2020-09
- 유형
- Article
- 권
- 21
- 호
- 3