Synthesis of Carborane-Fused Lactones via Electrochemical C(sp 3)-H Lactonization: Access to Benzofused Lactone Bioisosteres

초록

The replacement of the benzene ring with its bioisosteres is a powerful strategy in drug discovery, yet the development of ortho-disubstituted benzene bioisosteres, particularly fused-ring systems, remains underexplored. Herein, we report an electrooxidative protocol for the synthesis of carborane-fused lactones via C(sp 3)-H lactonization. This protocol provides concise access to carborane-fused gamma- and delta-lactone frameworks, which closely mimic the geometric features of benzofused lactones, thereby underscoring their potential as bioisosteres of benzofused lactones.

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