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초록
An efficient phosphaannulation via palladium( II)-catalyzed C-H activation/oxidative cyclization by the 6-endo mode is reported for the synthesis of 3-substituted phosphaisocoumarins from the reaction of arylphosphonic acids with unactivated alkenes under aerobic conditions. Also, alpha,alpha-disubstituted benzylphosphonic acids were phosphaannulated with unactivated alkenes, producing phosphaisochromanones having (Z)-alkylidenyl groups via anti-phosphoryloxypalladation by the 6-exo mode.
키워드
C-H activation; palladium; phosphaannulation; phosphaisochromanones; phosphaisocoumarins; PALLADIUM(II)-CATALYZED ORTHO-ARYLATION; BENZYLIC PHOSPHONIC MONOESTERS; BOND FORMATION; HYDROGEN PHOSPHATES; ORTHO-ALKENYLATION; ORTHO-OLEFINATION; EFFICIENT ROUTE; DIRECTING GROUP; PHOSPHAISOCOUMARINS; OXIDES
- 제목
- Phosphaannulation of Aryl- and Benzylphosphonic Acids with Unactivated Alkenes via Palladium-Catalyzed C-H Activation/Oxidative Cyclization Reaction
- 저자
- Jeon, Woo Hyung; Son, Jeong-Yu; Kim, Sun-Eung; Lee, Phil Ho
- 발행일
- 2015-03-09
- 유형
- Article
- 권
- 357
- 호
- 4
- 페이지
- 811 ~ 817