Lab-on-a-Chip Devices for Medical Diagnosis II: Strategies for Pathogen Detection

초록

The development of lab-on-a-chip technology is regarded as one of the most potent and reliable technologies for rapid and early detection of the pathogen with portable and on-site detection devices, the so-called point-of-care (PoC) detection systems. These are essentially easy to handle and cheap and offer rapid sample-to-answer results to nontechnical operators in a fast and accurate manner. A summary to provide an explanation about why lab-on-a-chip technology is one of the strategies for early detection of pathogens for medical diagnosis has been presented. The fabrication of the devices includes the three most important factors that are described. The devices are also implemented for the detection of various pathogens such as bacteria, protozoa, and virus, and also how each of the systems has specific ways to get the results. Furthermore, newly established detection sensing principles and application of the lab-on-a-chip and microfluidic devices are presented, and the remaining technical challenges and limitations are considered. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

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