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Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil
- Lee, Ji Hyun;
- Park, Han Na;
- Ganganna, Bogonda;
- Jeong, Ji Hye;
- Park, Sung-Kwan;
- ... Lee, Jongkook;
- 외 1명
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15초록
A newtadalafil analoguewas found, alongwith nortadalafil, using HPLC-DAD during the inspection of a health product sold without official approval. The analogue was separated using a semi-preparative HPLC system and its structure was determined by a combination of mass spectrometry and NMR spectroscopy. The compound was identified as a tadalafil analogue in which the N-methyl group of tadalafil was replaced with a tadalafil precursor moiety. Nuclear Overhauser effect spectroscopy experiments suggested a cis-relationship between the substituents on a piperidine ring in the tadalafilmoiety.
키워드
Tadalafil analogue; nortadalafil; bisprenortadalafil; PDE-5 inhibitor; dietary supplement; SEXUAL ENHANCEMENT PRODUCTS; ERECTILE DYSFUNCTION; COUNTERFEIT PRODUCTS; DIETARY-SUPPLEMENTS; VARDENAFIL; SILDENAFIL; HYPOGLYCEMIA; SINGAPORE; QUALITY; SAFETY
- 제목
- Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil
- 저자
- Lee, Ji Hyun; Park, Han Na; Ganganna, Bogonda; Jeong, Ji Hye; Park, Sung-Kwan; Lee, Jongkook; Baek, Sun Young
- 발행일
- 2016
- 유형
- Article
- 저널명
- Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
- 권
- 33
- 호
- 6
- 페이지
- 945 ~ 952