Effect of cubic phase nanoparticle on obesity-suppressing efficacy of herbal extracts

초록

The adipocyte differentiation-inhibiting efficacies of cubic phase nanoparticle/herbal extract mixture suspensions were much higher than those of herbal extract suspensions (grape, apple, mugwort, barberry root, and green tea). Confocal laser scanning microscopy and fluorescenceactivated cell sorting analysis revealed that cubic phase nanoparticle promoted the internalization of a watersoluble dye (e.g. calcein) into adipocyte cell. Cubic phase nanoparticle/herbal extract mixture suspensions decreased the blood contents of aspartate aminotransferase, total cholesterol, triglyceride, urea nitrogen, and low density lipoprotein more than herbal extract suspensions. Cubic phase nanoparticle also promoted the efficacy of the herbal extracts in suppressing the body weight gain and the liver weight of rats. The amount permeated through hairless mouse skin was higher when cubic phase nanoparticle was included in barberry root extract suspension.

키워드