Magnetocardiographic pattern analysis of re-entry wave propagation in three-dimensional ventricular tissue by using a human cardiac cell model

초록

We present a computational study of re-entry wave propagation which were does using an electrophysiological model of a human ventricular cell and the associated magnetic field map in three-dimensional (3D) cardiac tissue. A re-entry wave caused by cardiac disease can induce ventricular fibrillation, the major cause of sudden cardiac death. Magnetocardiographs (MCG) can detect early heart muscle ischemia. However, the clinical parameters for using MCGs to identify heart ischemia are poorly understood. Therefore, we examined the details of the magnetic field variation and related physiological parameters for a re-entry wave in 3D cardiac tissue. We used a new human cardiac cell model to simulate action potential (AP) propagation in a 3D rectangular parallelepiped block of tissue, and a finite element method and Galerkin approximation to discretize the 3D domain spatially. The re-entry wave was generated using an S1-S2 protocol. Calculations of the magnetic field pattern were based on the assumption of a horizontally layered conductor for re-entry wave propagation in the 3D cardiac tissue. Our results support previous findings. We also compared the AP and MCG magnitude during re-entry wave propagation to those during normal wave propagation. The temporal changes in the re-entry wave motion and the magnetic field map patterns were also analyzed with well-known MCG parameters, the current dipole direction and strength.

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