Synthesis of Phosphaisocoumarins through Rhodium-Catalyzed Cyclization Using Alkynes and Arylphosphonic Acid Monoesters

Seo, Jungmin; Park, Youngchul; Jeon, Incheol; Ryu, Taekyu; Park, Sangjune; Lee, Phil Ho

doi:10.1021/ol401407v

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Synthesis of Phosphaisocoumarins through Rhodium-Catalyzed Cyclization Using Alkynes and Arylphosphonic Acid Monoesters

Seo, Jungmin;
Park, Youngchul;
Jeon, Incheol;
Ryu, Taekyu;
Park, Sangjune;
외 1명

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WEB OF SCIENCE

95

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SCOPUS

101

초록

A rhodium-catalyzed cyclization using alkynes and arylphosphonic acid monoesters for the synthesis of phosphaisocoumarins is reported. A number of arylphosphonic acid monoesters were selectively cyclized in high yields with functional group tolerance. In addition, unsymmetrical alkynes are applied in high regioselectivity.

키워드

H BOND ACTIVATION; ARYL HYDROGEN PHOSPHATES; OXIDATIVE CYCLOADDITION; DIRECT ARYLATION; AROMATIC AMIDES; C-C; FUNCTIONALIZATION; ALKENYLATION; ISOCOUMARINS; SELECTIVITY

제목: Synthesis of Phosphaisocoumarins through Rhodium-Catalyzed Cyclization Using Alkynes and Arylphosphonic Acid Monoesters

저자: Seo, Jungmin; Park, Youngchul; Jeon, Incheol; Ryu, Taekyu; Park, Sangjune; Lee, Phil Ho

DOI: 10.1021/ol401407v

발행일: 2013-07-05

유형: Article

저널명: Organic Letters

권: 15

호: 13

페이지: 3358 ~ 3361