Oxidation-responsive cubic phase incorporating poly(hydroxyethyl acrylamide-co-phenyl vinyl sulfide)

초록

Oxidation-responsive monoolein (MO) cubic phase was prepared by including poly(hydroxyethyl acrylamide-co-phenyl vinyl sulfide) (P(HEAA-co-PVS)) in the water channel of the cubic phase. X-ray photon spectroscopy revealed that the sulfide moiety (i.e., the PVS unit) of the copolymers was oxidized to the sulfoxide moiety and the sulfone one after they were treated with H2O2. The interfacial activity of P(HEAA-co-PVS) markedly decreased by H2O2, possibly because the PVS unit was oxidized and the amphiphilicity of the copolymer decreased. The release degree of Allura Red AC (a dye) loaded in the cubic phase containing P(HEAA-co-PVS) was higher as the H2O2 concentration was higher. The copolymer would lose most of its surface activity upon oxidation and it could diffuse out of the water channel, leading to a reduction in the diffusion resistance and a promoted release.

키워드