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Chronic hepatotoxicity of carbon tetrachloride in HSP-70 knock out mice
- Park, DH;
- Lee, MS;
- Kim, HJ;
- Kim, HS;
- Lee, YL;
- ... Lee, MJ;
- 외 2명
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WEB OF SCIENCE
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SCOPUS
5초록
The chronic hepatotoxic effects of carbon tetrachloride (CCl4) in heat-shock protein (HSP) 70 knock out (HSP70-/-) mice were examined. After repeated intraperitoneal injections of CCl4 for six weeks, the level of ALT and weight ratio of the liver to body were lower in HSP70-/- mice than in the control (WT) mice. The levels of HSP25 and HSP47 were lowered in HSP70-/- mice as compared with WT mice. The grades of hepatic necrosis and neutrophil infiltration were not significantly different between HSP70-/- and WT mice. The collagen content was not affected significantly by CCl4 treatment.
키워드
CCl4; chronic hepatotoxicity; HSP-70; knock out mice; SHOCK-PROTEIN INDUCTION; GENE-EXPRESSION; LIVER FIBROSIS; COLLAGEN; INJURY; RAT
- 제목
- Chronic hepatotoxicity of carbon tetrachloride in HSP-70 knock out mice
- 저자
- Park, DH; Lee, MS; Kim, HJ; Kim, HS; Lee, YL; Kwon, MS; Jang, JJ; Lee, MJ
- 발행일
- 2004-01
- 유형
- Article
- 권
- 53
- 호
- 1
- 페이지
- 27 ~ 30
- 언어
- ENG
- 출판사
- INT PRESS EDITING CENTRE INC
- 발행국가
- 일본
- 분량
- 4 페이지
- ISSN
- E 1881-7122
P 1341-1357