국화과 약용 식물의 면역증진활성 검색

초록

The biological activities of immune modulating activities of the extracts from Echinacea purpurea, Chrysanthmum indicum L. and Circium japonicum var. ussuriense KITAMURA were compared. About 70% of the growth of human hepatocarcinoma and 80% of juman gastric cancer cell was inhibited in adding 0.5㎎/㎖ of the ethanol extracts of Echinacea purpurea, Chrysanthmum indicum L. and Circium japonicum var. ussuriense KITAMURA, respectively. The growth of human breast cancer cells was also inhibited in adding 0.5㎎/㎖ of the extracts as well as 60% of the human cancer cells. It was proved that the growth of human normal lung cell, scored as 5% for the extracts. Overall selectivity of the extracts on several human cancer cell line was over 3, which is higher than those from the conventional herbs. The growth of both human immune B and T cells was enhanced up to 1.4 to 2.0 times by adding the extracts, compared to the controls. The secretion o tumor necrosis factor-alpha(TNF-α) from T cell was also increased up to 94pg/㎖ in adding the Echinacea purpurea ethanol extract(0.5㎎/㎖ ). Circium japonicum var. ethanol extract also increased up to about 96pg/㎖ of interleukin-6(IL-6) from B cell.