어린 cocker spaniel 종에서 발생한 신부전증

초록

In the present study, we address systemically a case of renal disease developed in a 1 year-old male cockerand pathological examinations. The animal has been sufferedfrom renal dysfunction signs such as polyuria, anorexia, vomiting, diarrhea and weight loss. The dog was very weakand emaciated and had foamy contents with foul-smell in oral cavity. The animals showed notable decrease in thenumber of red blood cells and severe decreases of hemoglobin and hematocrit with or without changes of meancorpuscular volume and mean corpuscular hemoglobin concentration values, indicating microcytic or normocytichypochromatic anemia. In serum chemistry, blood urea nitrogen, creatinine, phosphorous, Na and Cl, which areassociated with renal function, were dramatically increased. In addition, alanine aminotransferase, aspartate transferase,alkaline phosphatase, cholesterol, lipase and amylase were also significantly elevated, while K concentration was notablydecreased. Urinalysis indicated prominent proteinuria with increase of bilirubin. Despite of symptomatic treatments,the dog was getting worse in healthy condition and dead in the end. At necropsy, both kidneys were brownish, pale,ts. Histologically, the kidneys indicated prominent segmentalor diffuse interstitial fibrosis in cortex and medulla as well as glomerulonephritis. The clinical signs, clinical pathologyand histopathological abnormalities of the young dog presented were consistent with chronic glomerulonephropathy,which was suspected to be a case of familial renal disease in the juvenile cocker spaniel dog.

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