이중 코팅된 압착 펠렛으로부터 3종 영양소의 방출 제어

초록

The purposes of this study were to prepare dual-layered coated compact pellets containing three nutrients (Glucose, Chromium picolinate, Vitamin C) for rumen bypass. The core compact pellets were prepared by an extrusion-spheronization method and then double layered coated with pH independent EC (ethyl cellulose) and pH-dependent polymers (EudragitR E100) using a fluid-bed spray coater. Depending on the coating levels of EC and EudragitR E100, release profiles were variable in simulated rumen (pH 6.8) and abomasums (pH 2.0) fluid using USP apparatus I (basket method). When compact pellets were coated with EC (about 10% level in inner layer) and then EudragitR E100 (20% level in outer layer) in a dual-layered manner, rumen-bypass delivery resisting rumen fluid followed by release in abomasums fluid could be possible. The friability was also satisfactory based on chewing behavior of ruminants. The dual-layered coated compact pellets showed smooth surface and distinct inner/outer layers using scanning electron microscopy (SEM). The current rumen bypass delivery system can be also applicable to deliver other nutrients in ruminants.

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