Immunomodulatory Effects of Non-saponin Red Ginseng Components on Innate Immune Cells

초록

Macrophages and NK cells play an important role in the first line of immunologic effects against tumor cells. We therefore assessed the effects of non-saponin red ginseng components (NSRG) on NK cell and macrophage tumoricidal activities, and the mitogen-stimulated lymphoproliferative response. When NK cells were treated with various concentrations of NSRG (100-300 ug/ml) for 4 h, tumoricidal activity was significantly increased. However, NSRG had effects on tumoricidal activity of macrophages at low concentration (1 ug/ml), which was not related to the production of nitric oxide. The mitogen response of lymphocytes to LPS and ConA in the spleen did not show significant differences between the control and NSRG-treated cells, whereas LPS-induced blastogenesis was slightly increased at 100g/ml (p < 0.05). These results suggest that NSRG has differential effects on innate immune response and could be useful as immunotherapy for cancer treatment.

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