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Aldose Reductase Inhibitors from the Leaves of Salix hulteni
- Park, Hyun Young;
- Kim, Hye Kyung;
- Jeon, Seong Ho;
- Kim, Soo Hee;
- Chun, Wan Joo;
- ... Kim, Myong Jo;
- ... Kwon, Yong Soo;
- 외 1명
Citations
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10초록
From the n-BuOH soluble fraction of the leaves of Salix hulteni, six compounds were isolated as aldose reductase inhibitors. On the basis of spectral data, these compounds were identified as diosmetin-7-O-beta-D-glucoside (1), isoquercitrin (2), diosmetin-7-O-beta-D-xylosyl-(1 -> 6)-beta-D-glucoside (3), aromadendrin-3-O-beta-D-glucoside (4), astragalin (5), and p-hydroxyacetophenone glucoside (6). All of the isolates were evaluated in vitro for inhibitory activity against the aldose reductase. Of these, compounds 1-5 exhibited inhibitory activity against aldose reductase with IC50 values ranging 1.4 to 5.8 mu M.
키워드
diabetic complications; flavonoids; human aldose reductase; inhibitory activity; leaves; Salix hulteni; CONSTITUENTS
- 제목
- Aldose Reductase Inhibitors from the Leaves of Salix hulteni
- 저자
- Park, Hyun Young; Kim, Hye Kyung; Jeon, Seong Ho; Kim, Soo Hee; Chun, Wan Joo; Lim, Soon Sung; Kim, Myong Jo; Kwon, Yong Soo
- 발행일
- 2009-10
- 유형
- Article
- 권
- 52
- 호
- 5
- 페이지
- 493 ~ 497