Assessment of Bioactive Compounds and Anti-Atopic Effect of Ecklonia cava and Ecklonia stolonifera by Bioconversion; 생물전환에 의한 감태 및 곰피 추출물의 유효성분 함량 및 아토피 피부염 개선 효과

초록

Atopic dermatitis is a chronic dermatitis caused by the immune imbalance of Th1 and Th2. This study evaluates and compares alleviation of the hyperimmune response due to immune imbalance of Th1 and Th2 after exposure to Ecklonia cava (EC), Ecklonia stolonifera (ES), fermented Ecklonia cava (FEC), and fermented Ecklonia stolonifera (FES). The contents of dieckol in EC, FEC, ES and FES were determined to be 8.53±0.33 mg/g, 7.51±0.21 mg/g, 1.42±0.32 mg/g, and 0.84±0.10 mg/g, respectively. The β-glucan content in EC, FEC, ES, and FES was 24.31± 0.71 mg/g, 38.22±0.92 mg/g, 34.70±0.83 mg/g, and 58.35±0.46 mg/g, respectively. We also investigated the anti-atopic effect of EC, FEC, ES, and FES on TNF-α/IFN-γ-induced HaCaT cells by evaluating the production of MDC, TARC, and IL-6. Compared to EC and ES, exposure of TNF-α/IFN-γ-induced HaCaT cells to FEC and FES significantly reduced the production of IL-6, MDC, and TARC. The pre-treatment of HaCaT cells with FEC, and FES was observed to inhibit the TNF-α/IFN-γ-induced nuclear transcription factor, NF-κB, Jak1, and STAT1. These results indicate the potential of FEC and FES to be used as functional ingredients for improving atopic dermatitis. © 2023 The Korean Society of Food Science and Nutrition.

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