Synthesis and In Vitro Antibacterial Activity of Cephalosporins with a Pyridinium Substituent Carrying an Isoxazole Moiety at the C-3 Position

Park, Haeil; Choi, Hyunjoo; Jang, Jinhee; Choi, Sunghak; Rhee, Jaekeol; Chang, Minsun

doi:10.1007/BF02976473

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Synthesis and In Vitro Antibacterial Activity of Cephalosporins with a Pyridinium Substituent Carrying an Isoxazole Moiety at the C-3 Position

Park, Haeil;
Choi, Hyunjoo;
Jang, Jinhee;
Choi, Sunghak;
Rhee, Jaekeol;
외 1명

Citations

SCOPUS

1

초록

Several quaternary pyridinium cephalosporin analogues were prepared and evaluated in vitro for antibacterial activity against selected Gram-positive and Gram-negative organisms. Most of the synthesized analogues were either as effective or less effective against the tested bacterial organisms than the reference compounds, Cefpirome and Ceftazidime.

키워드

Anti-pseudomonal activity; Anti-staphylococcal activity; Isoxazole moiety; Quaternary pyridinium cephalosporin

제목: Synthesis and In Vitro Antibacterial Activity of Cephalosporins with a Pyridinium Substituent Carrying an Isoxazole Moiety at the C-3 Position

저자: Park, Haeil; Choi, Hyunjoo; Jang, Jinhee; Choi, Sunghak; Rhee, Jaekeol; Chang, Minsun

DOI: 10.1007/BF02976473

발행일: 2001

유형: Article

저널명: Archives of Pharmacal Research

권: 24

호: 2

페이지: 89 ~ 94