Synthesis of Azulenopyridinones through Palladium-Catalyzed Oxidative [4+2] Cyclization Reactions ofN-Methoxyazulene-1-and 2-carboxamides with Alkynes

초록

Palladium-catalyzed oxidative [4+2] cyclization reactions were developed from the C-H activation reaction ofN-methoxyazulene-1- and 2-carboxamides with symmetrical and unsymmetrical alkynes under a molecular oxygen atmosphere, producing azulenopyridinone derivatives with novel azulene skeletons in good to excellent yields with a wide substrate scope and excellent functional group tolerance.

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