The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activities

초록

Cereal crops have recently experienced increased interest due to their potential health benefits. It has been suggested that the intake of whole grain foods is beneficial to the prevention and management of diabetes mellitus. In this study, we investigated the inhibitory effect of 70% EtOH extracts from different cultivars of sorghum, foxtail millet and proso millet on alpha-glucosidase and alpha-amylase. Among the six sorghum cultivars, Mongdang-susu(SS-1), Me-susu(SS-2), Susongsaengi-susu(SS-3) and Sikyung-susu(SS-4) extracts exhibited higher inhibitory activities against alpha-glucosidase (IC50 = 1.1-1.4 mu g/ml) than acarbose, reference inhibitor (IC50 = 2.1 mu g/ml). In addition, these extracts strongly inhibited degradation of starch by pancreatic and salivary alpha-amylase, whereas extracts from foxtail and proso millets exhibited no visible or detectible inhibitory effect on alpha-amylase or on alpha-glucosidase activity. These in vitro studies indicate the potential of sorghum in the development of effective anti-diabetic agents. (C) 2010 Elsevier Ltd. All rights reserved.

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