Standardized pectolinarin rich-Cirsium setidens Nakai extract attenuates bisphenol A-induced the 3T3-L1 adipocytes differentiation and obese C57BL/6J mice via the suppression of adipogenesis-related transcription factors

초록

Endocrine-disrupting chemicals (EDCs), called obesogens, play an important role in obesity by mimicking or disrupting bioidentical hormones. In this study, we determined the obesogenic effect of bisphenol A (BPA) and evaluated the anti-obesogenic effects of a standardized Cirsium setidens Nakai ethanolic extract (CNE) as a functional food ingredient on the lipid accumulation and expression of key adipogenic transcription factors (ATFs) in 3 T3-L1 adipocytes and C57BL/6J mice. The underlying mechanism of the obesogenic effect of BPA was confirmed using the peroxisome proliferator-activated receptor gamma (PPAR gamma) antagonist, GW9662. In addition, the anti-obesogenic effects of CNE were confirmed by measuring the lipid accumulation, reactive oxygen species (ROS) production, body and adipose tissue weights, and the adipogenesis- and lipogenesis-related proteins in BPA-induced 3T3-L1 adipocytes and obese mice. These findings indicate that CNE could potentially be used as a promising natural means to prevent BPA-induced obesity and obesity-related metabolic diseases.

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