Cytotoxic and anti-angiogenic effects of lanostane triterpenoids from Ganoderma lucidum

초록

Two new lanostane triterpenes, 3 alpha, 12 beta, 15 alpha-triacetoxy-5 alpha-lanosta-7,9(11), 24-trien-26-oic acid (1) and 5 alpha-lanosta-8,24-diene-26,27-dihydroxy-3,7-dione (2), together with sixteen known compounds (3-18) were isolated from the fruiting bodies of the Vietnamesemushroom Ganoderma lucidum. Their chemical structures were determined by extensive spectroscopic (IR, HR-EI-MS, 1D and 2D NMR) analyses. Potential cytotoxic activities of these compounds were evaluated against human non-small cell lung adenocarcinoma (A549), breast adenocarcinoma (MCF-7), and prostatic small cell carcinoma (PC-3). Among the compounds, 3 alpha, 12 beta, 15 alpha-triacetoxy-5 alpha-lanosta-7,9(11), 24-trien-26-oic acid (1) showed significant cytotoxic activity against PC-3 cells with an IC50 of 11.5 mu M. In studies of anti-angiogenesis activity, ganoderic acid F (17) was found to have the most potent inhibitory effect on the formation of capillary-like structures of human umbilical vein endothelial cells. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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