New guaiane sesquiterpenes from the fruits of Torilis japonica

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17

초록

Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4-guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

키워드

Torilis japonicaumbelliferaenitric oxide production inhibitorguaiane sesquiterpenoidCELLS
제목
New guaiane sesquiterpenes from the fruits of Torilis japonica
저자
Lee, In-KyoungLee, Jeong-HyungHwang, Eui I. I.Yun, Bong-Sik
DOI
10.1248/cpb.56.1483
발행일
2008-10
유형
Article
저널명
Chemical and Pharmaceutical Bulletin
56
10
페이지
1483 ~ 1485