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Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides
- Koo, H;
- Lee, SY;
- Shin, KH;
- Kim, BC;
- Lirn, CJ;
- 외 1명
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104초록
The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25 - 100 muM on the growth of the transformed NlH3T3 cell line.
키워드
IRIDOID GLUCOSIDES
- 제목
- Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides
- 저자
- Koo, H; Lee, SY; Shin, KH; Kim, BC; Lirn, CJ; Park, EH
- 발행일
- 2004-05
- 유형
- Article
- 저널명
- Planta Medica
- 권
- 70
- 호
- 5
- 페이지
- 467 ~ 469
- 언어
- ENG
- 출판사
- GEORG THIEME VERLAG KG
- 발행국가
- 독일
- 분량
- 3 페이지
- ISSN
- E 1439-0221
P 0032-0943