Antioxidant and anticancer activities of methanol and water extracts from leaves of Cirsium japonicum

초록

Potential antioxidant activities of methanol and water extracts of Cirsium japonicum var. ussuriense (CJ) leaves were examined. The reducing power and hydroxyl raical-scavenging activity assays showed that the methanol extract had a significantly higher activity than the water extract. In addition, the methanol extract showed a concentration-dependent reducing power, ranging from 0.228 to 1.072 (0.1∼0.5 mg/mL), as well as a high DPPH free radical-scavenging activity (EC<inf>50</inf>= 40.25 μg/mL). The total phenolic (as tannic acid) and flavonoid (as quercetin) contents of the extract were 62.41 mg/g and 13.48 mg/g, respectively. The cytotoxic activity indicated that the methanol extract has an inhibition activity in the stomach carcinoma cell (35.40%), suggesting that the methanol extract of CJ leaves could be used as a potential source of pharmaceutical material.

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