A small molecule inhibitor of α4 integrin-dependent cell migration

Lee, Jongkook; Hong, Jiyong; Nam, Tae-Gyu; Peters, Eric C.; Orth, Anthony P.; Geierstanger, Bernhard H.; Goldfinger, Lawrence E.; Ginsberg, Mark H.; Cho, Charles Y.; Schultz, Peter G.

doi:10.1016/j.bmc.2008.02.067

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A small molecule inhibitor of α4 integrin-dependent cell migration

Lee, Jongkook;
Hong, Jiyong;
Nam, Tae-Gyu;
Peters, Eric C.;
Orth, Anthony P.;
외 5명

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7

초록

A small molecule inhibitor of alpha 4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha 4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases. (C) 2008 Elsevier Ltd. All rights reserved.

키워드

COTTON-TOP TAMARIN; GAMMA-PARVIN; ANTAGONISTS; ANTIBODY; KINASE; LIBRARIES; COLITIS; BINDING

제목: A small molecule inhibitor of α4 integrin-dependent cell migration

저자: Lee, Jongkook; Hong, Jiyong; Nam, Tae-Gyu; Peters, Eric C.; Orth, Anthony P.; Geierstanger, Bernhard H.; Goldfinger, Lawrence E.; Ginsberg, Mark H.; Cho, Charles Y.; Schultz, Peter G.

DOI: 10.1016/j.bmc.2008.02.067

발행일: 2009-02-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry

권: 17

호: 3

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