운동 강도에 따른 혈중 세로토닌과 전염증성 사이토카인 변화에 관한 연구

초록

The purpose of this study was examine the effects of differenet xercise intensities on blood serotonin and pro-inflammatory cytokine. There is strong evidence for conneciotn between pro-inflammatory cytokine and depression. Also, imbalance in the production and transmissiono f serotonin is commonly observed in the central nervous system in major depression. All subjects performed running test at two different kinds of exercise intensities, 50% V·O2max and 85% V·O2max, respectively. Blood-sampling was carried out 4 times(rest, end of exercise, 1h post and 4h post exercise) for analysing blood serotonin, TNF-α, IL-1β, and IL-6. The results of study showd that the concentrations of serum serotonin, IL-6 and TNF-α were influenced by exercise intensity. So this study indicated that high intensity exercise than low-intensity exercise maybe has more positive effects on a person with depression and exercise intensity could be major factors of influence turnover rate of serotonin and pro-inflammatory cytokine metabolism. In summary, further studies are required to enable more definiivte and scientific conclusions, particularly in patients suffering from depression.

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