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Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
- Lee, Sung-Jin;
- Ahn, Hyunjin;
- Nam, Kung-Woo;
- Kim, Kyeong Ho;
- Mar, Woongchon
Citations
WEB OF SCIENCE
17Citations
SCOPUS
18초록
The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide (H2O2) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by 500 mu M H2O2, as assessed by 4',6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting.
키워드
Rutaecarpine; Oxidative stress; DNA damage; Quinone reductase; Apoptosis; Hydrogen peroxide; OXIDATIVE STRESS; RESPONSIVE ELEMENT; DNA-DAMAGE; CANCER; CHEMOPROTECTION; INHIBITION; INDUCTION
- 제목
- Effects of Rutaecarpine on Hydrogen Peroxide-Induced Apoptosis in Murine Hepa-1c1c7 Cells
- 저자
- Lee, Sung-Jin; Ahn, Hyunjin; Nam, Kung-Woo; Kim, Kyeong Ho; Mar, Woongchon
- 발행일
- 2012-09-30
- 유형
- Article
- 권
- 20
- 호
- 5
- 페이지
- 487 ~ 491