Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice

초록

Bisphenol A (BPA) is a representative endocrine-disrupting chemical that exhibits hormonaldisturbance reactions. Various alternatives, such as Bisphenol S (BPS) and Bisphenol F (BPF), arebeing developed. BPS and BPF (which are representative alternatives to BPA) are used inconsumer products such as polycarbonate plastics and epoxy resins. They have structuressimilar to those of BPA and have also been proven to be exogenous endocrine disruptors. However, although there are many studies on BPA, there are few studies on theneurodevelopmental effects of BPS and BPF. Therefore, in this study, we analyzedneurobehavioral changes in offspring mice exposed to BPS and BPF during brain developmentby administering BPS and BPF to pregnant mice. We found that prenatal exposure to BPS andBPF did not affect anxiety-and depression-like behaviors, locomotion, sociability, memory, orcognition functions in offspring mice. However, exposure to BPS and BPF decreased thepreference for social novelty in the offspring mice. Taken together, these findings suggest thatperinatal exposure to BPS and BPF affects changes in social behaviors, but not other behavioralchanges such as emotion, memory, or cognition in the offspring mice.

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