Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition

Choe, Hyeonjeong; Cho, Hyukjoon; Ko, Hyun-Jeong; Lee, Jongkook

doi:10.1021/acs.orglett.7b03054

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Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition

Choe, Hyeonjeong;
Cho, Hyukjoon;
Ko, Hyun-Jeong;
Lee, Jongkook

Citations

WEB OF SCIENCE

23

Citations

SCOPUS

24

초록

Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition of diene 4.

키워드

ASYMMETRIC TOTAL-SYNTHESIS; HSP90 INHIBITORS; STEM-CELLS; BIOLOGICAL EVALUATION; CONCISE SYNTHESES; RADICICOL; ANALOGS; CANCER; CHEMISTRY; LEUKEMIA

제목: Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition

저자: Choe, Hyeonjeong; Cho, Hyukjoon; Ko, Hyun-Jeong; Lee, Jongkook

DOI: 10.1021/acs.orglett.7b03054

발행일: 2017-11-03

유형: Article

저널명: Organic Letters

권: 19

호: 21

페이지: 6004 ~ 6007

언어: ENG

출판사: AMER CHEMICAL SOC

발행국가: 미국

분량: 4 페이지

ISSN: E 1523-7052
P 1523-7060