Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

Ryu, Jae Wook; Han, Sun-Young; Yun, Jeong In; Choi, Sang-Un; Jung, Heejung; Du Ha, Jae; Cho, Sung Yun; Lee, Chong Ock; Kang, Nam Sook; Koh, Jong Sung; Kim, Hyoung Rae; Lee, Jongkook

doi:10.1016/j.bmcl.2011.09.066

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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

Ryu, Jae Wook;
Han, Sun-Young;
Yun, Jeong In;
Choi, Sang-Un;
Jung, Heejung;
... Lee, Jongkook;
외 6명

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초록

A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T). (C) 2011 Elsevier Ltd. All rights reserved.

키워드

c-Met; Cancer; Kinase inhibitor; Triazolopyridazine; Methylisoquinolinone; CANCER; DISCOVERY; AMPLIFICATION; SENSITIVITY; ONCOGENE; RECEPTOR

제목: Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

저자: Ryu, Jae Wook; Han, Sun-Young; Yun, Jeong In; Choi, Sang-Un; Jung, Heejung; Du Ha, Jae; Cho, Sung Yun; Lee, Chong Ock; Kang, Nam Sook; Koh, Jong Sung; Kim, Hyoung Rae; Lee, Jongkook

DOI: 10.1016/j.bmcl.2011.09.066

발행일: 2011-12-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 21

호: 23

페이지: 7185 ~ 7188

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: E 1464-3405
P 0960-894X