Early Detection of Cardiac Injuries Related to Transcutaneous Pacing in Dogs Using Cardiac Biomarker Assay

초록

Evaluation of changes in concentrations of cardiac biomarkers and activities of enzymes in serum as indicators of cardiac injuries may be clinically important because the use of TCP is gaining popularity in the treatment of bradyarrhythmias in small animals. The purpose of the study reported here was to evaluate cardiac biomarker concentrations in serum in dogs with experimentally induced bradyarrhythinias after short duration (1 h) TCP. Marked elevation of serum concentration of cTnI was noticed immediately after TCP (day 0) compared with the baseline value. From day 0 through day 2, serum cTnI concentrations were significantly (p<0.05) increased. The expression level of NCX-1 using real-time PCR analysis was not significantly differed in blood samples taken from the different time point. Since, no study has evaluated biomarker levels after transcutaneous cardiac pacing this study may help to understand what kind and what type of cardiac injuries can be occurred.

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