Time-Course Changes and New Expressions of MIP-3 and Its Receptor, CCR6, in the Gerbil Hippocampal CA1 Area Following Transient Global Cerebral Ischemia

초록

Macrophage inflammatory protein-3 (MIP-3) and its sole receptor, CCR6, play pivotal roles in neuroinflammatory processes induced by brain ischemic insults. In this study, we investigated transient ischemia-induced changes in MIP-3 and CCR6 protein expressions in the hippocampal CA1 area following 5min of transient global cerebral ischemia (tgCI) in gerbils. Both MIP-3 and CCR6 immunoreactivities were very strongly expressed in pyramidal neurons of the CA1 area from 6h to 1day after tgCI and were hardly shown 4days after tgCI. In addition, strong MIP-3 immunoreactivity was newly expressed in astrocytes 6h after tgCI. These results indicate that tgCI causes apparent changes in MIP-3 and CCR6 expressions in pyramidal neurons and astrocytes in the hippocampal CA1 area and suggest that tgCI-induced changes in MIP-3 and CCR6 expressions might be closely associated with neuroinflammatory processes in brain ischemic regions.

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