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CAGE displays oncogenic potential and induces cytolytic T lymphocyte activity
- Shim, E;
- Shim, H;
- Bae, J;
- Lee, H;
- Jeoung, D
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10초록
The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8(+) T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.
키워드
cancer associated gene; cytolytic T lymphocytes; motility; reactive oxygen species; ANTIGEN GENE CAGE; IDENTIFICATION; EXPRESSION
- 제목
- CAGE displays oncogenic potential and induces cytolytic T lymphocyte activity
- 저자
- Shim, E; Shim, H; Bae, J; Lee, H; Jeoung, D
- 발행일
- 2006-04
- 유형
- Article
- 권
- 28
- 호
- 7
- 페이지
- 515 ~ 522