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Inhibitory activities of three compounds from Mucuna birdwoodiana on 3α-hydroxysteroid dehydrogenase
- Yong Soo Kwon;
- Jin Hun Lee;
- Chang Min Kim
Citations
SCOPUS
2초록
The NAD(P)-linked 3α-Hydroxysteroid dehydrogenase(3α-HSD) of rat liver cytosol is powerfully inhibited by the non-steroidal anti-inflammatory drugs in rank-order of their therapeutic potency, and this observation has now been developed into a rapid screen for predicting the potency of products that show antiinflammatory effect. Five-plants were screened by using this method. Among them, BuOH-fraction of Mucuna birdwoodiana showed strong inhibitory effect on 3α-HSD, and three isoflavone compounds were isolated. Inhibitory activities of isolated compounds were compared.
키워드
3α-Hydroxysteroid dehydrogenase; 4',8-dimethoxyisoflavone-7- O-β-D-glucoside; Anti-inflammatory effect; Birdwoodiana; Daidzin; Isoflavones; Leguminosae; Ononin
- 제목
- Inhibitory activities of three compounds from Mucuna birdwoodiana on 3α-hydroxysteroid dehydrogenase
- 저자
- Yong Soo Kwon; Jin Hun Lee; Chang Min Kim
- 발행일
- 1999
- 유형
- Article
- 저널명
- 생약학회지
- 권
- 30
- 호
- 2
- 페이지
- 216 ~ 221
- 언어
- KOR
- 분량
- 6 페이지
- ISSN
- P 0253-3073