1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells

Che, Haiyan; Truong Ngoc Tuyen; Kim, Hyun Pyo; Park, Haeil

doi:10.1016/j.bmcl.2010.05.092

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1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells

Che, Haiyan;
Truong Ngoc Tuyen;
Kim, Hyun Pyo;
Park, Haeil

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WEB OF SCIENCE

21

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SCOPUS

27

초록

A series of 1,5-diarylimidazoles with 4-methylsulfonylphenyl group were prepared and evaluated for the inhibitory activities against COX-2 catalyzed PGE(2) production from LPS-induced RAW 264.7 cells. Most of synthesized 1,5-diarylimidazoles exhibited strong inhibitory activities regardless of the position of the 4-methylsulfonylphenyl group. The 1,5-diarylimidazoles with a halogen atom (3c-3h, 3n-3p) gave mostly excellent inhibitory activities regardless of the position and species of the halogen atom. Whereas the 1,5-diarylimidazoles with two fluorine atoms (3k, 3l, 3r, 3s) showed rather reduced inhibitory activities. (C) 2010 Elsevier Ltd. All rights reserved.

키워드

1,5-Diarylimidazoles; Prostaglandin production; COX-2 Inhibitors; Anti-inflammatory activity; 4-Methylsulfonylphenyl group; CYCLOOXYGENASE-2

제목: 1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells

저자: Che, Haiyan; Truong Ngoc Tuyen; Kim, Hyun Pyo; Park, Haeil

DOI: 10.1016/j.bmcl.2010.05.092

발행일: 2010-07-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 20

호: 14

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