Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Shim, Eunsook; Lee, Yun-Sil; Kim, Hae Yeong; Jeoung, Dooil

doi:10.1007/s10529-006-9213-5

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Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

Shim, Eunsook;
Lee, Yun-Sil;
Kim, Hae Yeong;
Jeoung, Dooil

Citations

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8

Citations

SCOPUS

10

초록

The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility.

키워드

C-FLIP; motility; reactive oxygen species; serine/threonine kinase Akt; INDUCED APOPTOSIS; INCREASED EXPRESSION; MEDIATED APOPTOSIS; HYDROGEN-PEROXIDE; INHIBITOR; PROTEIN; GROWTH

제목: Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells

저자: Shim, Eunsook; Lee, Yun-Sil; Kim, Hae Yeong; Jeoung, Dooil

DOI: 10.1007/s10529-006-9213-5

발행일: 2007-01

유형: Article

저널명: Biotechnology Letters

권: 29

호: 1

페이지: 141 ~ 147