A New Isoflayone Glycoside from the Stem Bark of Sophora japonica

Park, Hyun Young; Kim, Soo Hee; Kim, Gi Beom; Sim, Jae Young; Lim, Soon Sung; Kim, Myong Jo; Chun, Wanjoo; Kwon, Yong Soo

doi:10.1007/s12272-010-0805-1

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A New Isoflayone Glycoside from the Stem Bark of Sophora japonica

Park, Hyun Young;
Kim, Soo Hee;
Kim, Gi Beom;
Sim, Jae Young;
Lim, Soon Sung;
... Kim, Myong Jo;
... Chun, Wanjoo;
... Kwon, Yong Soo

Citations

WEB OF SCIENCE

16

Citations

SCOPUS

19

초록

A new isoflavone glycoside, 6-methoxy-7-hydroxy-4'-O-beta-D-glucosyl isoflavone, D-glucoside (10), along with nine known flavonoids, were isolated from the stem bark of Sophora japonica. The structures of these compounds were determined by analysis of spectroscopic data (1D -, 2D - NMR and HRMS). The inhibitory effects of all the isolated compounds on aldose reductase were evaluated in vitro. Among these compounds, daidzein (1), puerol A (4), and paratensein-7-O-glucoside (9) exhibited potent inhibitory effects, with IC50 values of 3.2, 6.4, and 1.9 mu M, respectively.

키워드

Sophora japonica; Stem bark; Isoflavone glycoside; Glycitein-4 '-O-beta-D-glucoside; Aldose reductase; ALDOSE REDUCTASE; COMPLICATIONS

제목: A New Isoflayone Glycoside from the Stem Bark of Sophora japonica

저자: Park, Hyun Young; Kim, Soo Hee; Kim, Gi Beom; Sim, Jae Young; Lim, Soon Sung; Kim, Myong Jo; Chun, Wanjoo; Kwon, Yong Soo

DOI: 10.1007/s12272-010-0805-1

발행일: 2010-08

유형: Article

저널명: Archives of Pharmacal Research

권: 33

호: 8

페이지: 1165 ~ 1168