Effects of Fucoidan on NO Production and Phagocytosis ofMacrophages and the Proliferation of Neuron Cells

초록

Fucoidans, high-molecular-weight sulfated polysaccharides extracted from brown seaweeds, have various biological activities. Here we examined whether fucoidan could increase the immunomodulation and proliferation capacity of cells in vitro. When peritoneal macrophages were treated with various concentrations of fucoidan (1∼100 g/mL) for 24 hours, NO production was significantly increased. In addition, exposure of macrophages to 10 g/mL of fucoidan induced a phagocytic activity. Treatment of neuroblastoma cells (SK-N-SH) with fucoidan enhanced cell proliferation and NO production in a concentration-dependent manner. These results indicate that fucoidan has both immunomodulatory and cell proliferative properties, and may thus be a a candidate for development as an immunomodulating agent.

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