Copper diisobutyl-t-butoxyaluminum hydride: A novel reagent for chemoselective reduction of tertiary amides over esters

Im, So Hee; Shin, Won Kyu; Jaladi, Ashok Kumar; An, Duk Keun

doi:10.1016/j.tetlet.2018.04.082

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Copper diisobutyl-t-butoxyaluminum hydride: A novel reagent for chemoselective reduction of tertiary amides over esters

Im, So Hee;
Shin, Won Kyu;
Jaladi, Ashok Kumar;
An, Duk Keun

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5

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4

초록

We demonstrate that copper diisobutyl-t-butoxyaluminum hydride, readily prepared from lithium diisobutyl-t-butoxyaluminum hydride and Cul, effectively and chemoselectively reduces tertiary amides over esters at ambient temperature, affording the corresponding aldehydes in excellent yields. (C)2018 Elsevier Ltd. All rights reserved.

키워드

Chemoselective reduction; Tertiary amide; Ester; Aldehyde; CDBBA; EFFICIENT REDUCING AGENT; SELECTIVE REDUCTION; ORGANIC-COMPOUNDS; CARBOXYLIC-ACIDS; ALDEHYDES; ALUMINUM; TETRAHYDROFURAN; CONVERSION

제목: Copper diisobutyl-t-butoxyaluminum hydride: A novel reagent for chemoselective reduction of tertiary amides over esters

저자: Im, So Hee; Shin, Won Kyu; Jaladi, Ashok Kumar; An, Duk Keun

DOI: 10.1016/j.tetlet.2018.04.082

발행일: 2018-06-13

유형: Article

저널명: Tetrahedron Letters

권: 59

호: 24

페이지: 2335 ~ 2340