Single-dose, Randomized, Open-label, 2-way Crossover Study of the Pharmacokinetics of Amitriptyline Hydrochloride 10-and 25-mg Tablet in Healthy Male Korean Volunteers

초록

Purpose: Amitriptyline is the most widely used tricyclic antidepressant (TCA). Although amitriptyline hydrochloride 10 and 25 mg has been marketed in Korea, no data on the dose proportionality of amitriptyline in Korean subjects are available. This clinical trial was designed to evaluate and compare the relative bioavailability with regard to dose proportionality between the two marketed strengths of amitriptyline hydrochloride tablets after a single-dose, oral administration under fasting conditions in healthy, male, Korean volunteers. Methods: This single-dose, randomized, open-label, 2-way crossover study was conducted in healthy male Korean subjects. Subjects were randomly assigned to 1 of 2 dose groups and received a single dose of 10 or 25 mg amitriptyline hydrochloride under fasting conditions, followed by the alternate dose in the subsequent study period. High performance liquid chromatography (HPLC)-mass spectrometry (MS)/MS detection was applied to determine plasma concentrations. Pharmacokinetic parameters were calculated, C-max, AUC(last), AUC(0-infinity), t(1/2), and T-max. Statistical analysis was performed for the assessment of dose proportionality. Tolerability was assessed for up to 96 hours after administration. Findings: Twelve healthy Korean subjects completed this trial (mean [SD] age, 21.7 [1.9] years; height, 174.5 [5.0] cm; and weight, 66.7 [9.4] kg). Although 4 subjects experienced a total 5 adverse events (AEs), no serious AEs were reported during the study. The mean values of C-max and AUC were proportional to the doses of 10 and 25 mg. The C-max, AUC(last), and AUC(0-infinity) of amitriptyline hydrochloride 10 mg were 5.96 ng/mL, 91.35 ng.h/mL and 109.74 ng.h/mL, respectively. The C-max, AUC(last), and AUC(0-infinity) of amitriptyline hydrochloride 25 mg were 17.69 ng/mL, 260.68 ng.h/mL, and 296.87 ng.h/mL, respectively. (C) 2015 Elsevier HS Journals, Inc. All rights reserved.

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