Iridium-Catalyzed Cyclative Indenylation and Dienylation through Sequential B(4)-C Bond Formation, Cyclization, and Elimination from o-Carboranes and Propargyl Alcohols

Baek, Yonghyeon; Cheong, Kiun; Ko, Gi Hoon; Han, Gi Uk; Han, Sang Hoon; Kim, Dongwook; Lee, Kooyeon; Lee, Phil Ho

doi:10.1021/jacs.0c02121

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Iridium-Catalyzed Cyclative Indenylation and Dienylation through Sequential B(4)-C Bond Formation, Cyclization, and Elimination from o-Carboranes and Propargyl Alcohols

Baek, Yonghyeon;
Cheong, Kiun;
Ko, Gi Hoon;
Han, Gi Uk;
Han, Sang Hoon;
... Lee, Kooyeon;
외 2명

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75

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78

초록

Described herein is the first iridium-catalyzed cyclative indenylation through sequential B(4)-C and intramolecular C-C bond formation from o-carboranes and propargyl alcohols, leading to the formation of B(4)-indenylated o-carboranes with excellent regioselectivity via direct B-H activation. Moreover, the iridium-catalyzed regioselective 1,3-dienylation has been accessed through sequential B-H activation, dehydration, and decarboxylation, producing B(4)-dienylated o-carboranes.

키워드

CAGE B-H; BORON CLUSTERS; DRUG DISCOVERY; ACTIVATION; CHEMISTRY; FUNCTIONALIZATION; ALLENYLATION; AROMATICITY

제목: Iridium-Catalyzed Cyclative Indenylation and Dienylation through Sequential B(4)-C Bond Formation, Cyclization, and Elimination from o-Carboranes and Propargyl Alcohols

저자: Baek, Yonghyeon; Cheong, Kiun; Ko, Gi Hoon; Han, Gi Uk; Han, Sang Hoon; Kim, Dongwook; Lee, Kooyeon; Lee, Phil Ho

DOI: 10.1021/jacs.0c02121

발행일: 2020-06-03

유형: Article

저널명: Journal of the American Chemical Society

권: 142

호: 22

페이지: 9890 ~ 9895