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Cyclization of 1-Bromo-2,7-and 1-Bromo-2,8-Enynes mediated by indium
- Lee, PH;
- Kim, S;
- Lee, K;
- Seomoon, D;
- Kim, H;
- 외 5명
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32초록
[Graphics] The cyclization of 1-bromo-2,7- and 1-bromo-2,8-enynes mediated by indium in DMF produced five- and six-membered cyclic compounds. Although KI was a necessary additive in the cyclization of terminal 1-bromo-2,7-enynes to give the desired products at 25degreesC, reactions of terminal 1-bromo-2,8-enynes and internal 1-bromo-2,7-enynes with indium proceeded at 100degreesC in DMF without KI. After cyclizations, subsequent cross-coupling reaction and iodolysis increase the usefulness of this reaction.
키워드
CROSS-COUPLING REACTIONS; CARBON TRIPLE BONDS; REFORMATSKY REACTION; ALPHA,BETA-UNSATURATED KETONES; CYCLOPENTENE ANNULATION; FUNCTIONALIZED ALKYNES; BETA-HYDROXYESTERS; ORGANIC-REACTIONS; EFFICIENT METHOD; ARYL HALIDES
- 제목
- Cyclization of 1-Bromo-2,7-and 1-Bromo-2,8-Enynes mediated by indium
- 저자
- Lee, PH; Kim, S; Lee, K; Seomoon, D; Kim, H; Lee, S; Kim, M; Han, M; Noh, K; Livinghouse, T
- 발행일
- 2004-12-23
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 6
- 호
- 26
- 페이지
- 4825 ~ 4828