Comparative analysis of bioactive compounds and the anti-inflammatory and wound-healing properties of Centella asiatica

초록

Centella asiatica and its compounds, such as asiaticoside, madecassoside, madecassic acid, and asiatic acid, have been used in pharmaceutical and cosmetic products due to their anti-inflammatory and skin-regenerating effects. This study assessed the potential of Jeju-grown Centella asiatica as a substitute for imported varieties by analyzing bioactive compound content and evaluating anti-inflammatory and wound-healing effects. Samples collected from three Jeju regions were analyzed monthly using HPLC for triterpenoids (asiaticoside, madecassoside, asiatic acid, and madecassic acid). Sangmo-ri samples showed consistently high asiaticoside levels. Seasonal variation was noted, with peak compound levels in August-September. Anti-inflammatory activity, evaluated in lipopolysaccharide-stimulated RAW 264.7 macrophages and HaCaT keratinocytes, showed that Jeju extracts effectively suppressed NO production and inflammatory cytokines (iNOS, COX-2, IL-1β, and IL-6), comparable to or better than Vietnamese and French imports. Wound-healing assays in HaCaT cells revealed that Jeju extracts promoted faster wound closure, particularly from June to August. Overall, Jeju Centella asiatica demonstrates strong potential as a domestic alternative to imported sources, with consistent anti-inflammatory and wound-healing effects and high bioactive compound content, primarily when harvested in late summer. © The Korean Society for Applied Biological Chemistry 2025.

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