In vitro Release Characteristics of Nitroglycerin fromMicroemulsion-Based Hydrogel System for Anal Fissure Treatment

초록

To develop topical nitroglycerin (NTG) preparation for chronic anal fissure treatment, the release rate of NTG should be controlled carefully. For this, microemulsion was prepared from the phase diagram construction with Cremophor ELPR, ethanol and Labrafil M1944CSR and the topical gel was prepared by dispersing NTG containing microemulsion into hydrophilic polymers. In vitro release characteristics were evaluated with Franz diffusion cell using cellulose membrane and compared with control hydrogels. The release rate of NTG was followed 1st order kinetics and ,when comparing the NTG release from control hydrogel with that from the microemulsion-based hydrogel, the NTG release rate was controlled by the content of polymers within continuous phase and the concentration of dispersed phase.

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