Hematological manifestations in dogs progressing tothe iron deficiency anemia by repeated phlebotomy

초록

dogs by repeated phlebotomy to characterize hematologic features, serum iron values, and RBC indices.Abnormal RBC morphologies were also evaluated semiquantitatively on Wright’s-stained blood films.Hematologic abnormalities in early stage of anemia included decreased both hematocrit and hemoglobin,and reticulocytosis, with no changes in mean corpuscular volume (MCV) and mean corpuscular hemog-with microcytosis and hypochromia were prominent. In late stage, red cel distribution width andMentzer’s index were out of reference ranges in the majority of dogs. In this study microcytic anemiawas appeared at the hemoglobin range of 5.1-7.2 g/dl. On most sampling days, platelet counts and whiteblood cells were within the reference ranges, with some minor variations. Iron deficiency was notMCHC, 3 paterns of anemia were sequentially observed: initially normocytic normochromic, intermediatenormocytic hypochromic or normocytic normochormic, and finally microcytic hypochromic. The mostfrequent morphologic abnormalities were target cells. Occasional elliptocyte, acanthocyte, stomatocyte,kinzocyte, dacrocyte and schistocyte were also noted on the blood films.

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